Just as there are many kinds of Divergence, there are many kinds of Progenitors. Some use scientific means to break the soul, while others use mysticism. Some stumble upon the Divergence by accident while pursuing some other goal, while for others its was always the intention, even if the Variations of their victims aren't exactly what was intended. Few Progenitors fully understand what it is they're doing when they inflict the Divergence, which is why the process is so unpredictable and prone to failure. Those Progenitors with access to the most resources and no qualms about their body count may nevertheless refine their methods to the point that they can somewhat reliably control the process.
The motives of Progenitors are diverse. Some have clear instrumental or practical goals, but for others, the Remade is an art project or a philosophical statement. Some of them just inflict Divergence to see if they can. Conspiracies actively recruit Progenitors with the hope of controlling the production of new Deviants.
Relationship to the Remade
For many Renegades, the hatred and fury they feel at their Progenitor is one of the few things keeping them stable. For others, the relationship is more complicated, an intense love-hate similar to how an abused child might feel towards their only parent. Not all Deviants know their Progenitor, however. Genotypals, for instance, may not undergo the Divergence until their Progenitor is long dead, while Pathologicals are the result of accidents and often don't have a single clear Progenitor.
Some Deviants are self-made: they were their own Progenitor, whether accident or by plan. These lucky few are usually better at evading conspiracies, at least initially, and have somewhat more resilience in dealing with their condition.