After the first exchanges of blows with his enemy, Horus began building a vast network of other supernatural creatures in order to oppose Set and protect Egypt from his vile influence. It was during these negotiations that Horus learned about the Jyhad and swore to avenge his father by exterminating the whole brood of Caine.
During the periods Horus had spent within the Underworld, the League was not stable and repeatedly collapsed. This was one of the prime motivations for Horus to create others like him, in order to maintain the League.
After Alexander the Great conquered Egypt, the League finally fell apart and each member fought Set and his followers in their own ways.
At certain points of history, the Osirian League has included: