May 21

2002
- HTR: Hunter: The Reckoning (video game) is released on XBox.
- HTR: Hunter: The Reckoning Soundtrack

2003
- Lily thinks it may be getting serious with Rolf. He said he's got something very special to give her next week.^[1]

1453
- The siege of Constantinople grinds on. Ottoman casualties mount as Byzantium whittles away the forces that crash against her walls. Sapper tunnels are set aflame almost as they are dug. Two Janissaries die for each fallen soldier they attempt to reclaim. Halil Pasha urges Mehmet II to retreat, Zagan Pasha (his second vizier) pushes for an immediate heavy attack. Mehmet splits the difference, and offers to lift the siege; his terms are unconditional surrender. If Constantinople is surrendered to him, the Byzantine people will be allowed to live, and the Emperor will be recognized as a governor to the Ottoman Empire’s Peloponnesian province. But while Constantine in turn offers broad concessions, he refuses to surrender the city. He tells the sultan that "...we have all decided to die with our own free will and we shall not consider our lives."^[2]

2001
- The Triton Foundation announces a gene-therapy treatment for prostate cancer and a genetic screening process that predicts (with 94% accuracy) whether a person will develop any of the common forms of cancer.^[3]

2006
- Convicted kidnapper and alleged cannibal Stanley Jason Weltey (a.k.a. "Brother Elias"), a member of the Church of Astaroth, is sentenced to six consecutive life terms without parole in Springfield, MO, in connection with the abduction and disappearance of six infants. His defense calls it religious persecution.^[4]