Marissa claimed the princedom of Washington, D.C. after the former prince fell victim to a sudden Assamite attack. Her own clan supported her claim, going as far as to grant her the rank of Pontifex, despite initial concerns. Marissa used the racist tendencies among the American population following the Civil War to secure her power and hoard many magical artifacts for her own use.
Strong alliances with the Nosferatu, vicious anti-Anarch propaganda, Victorian-style leadership, and her own natural charm were the foundation of her power. Some of the Kindred even dared to proclaim her "Queen of the United States". Marissa's gender, however, made her unpopular among the patriarchal Tremere, who sent a replacement for her. The replacement mysteriously vanished on its way to Washington.
When the Ventrue Marcus Vitel arrived in Washington, Marissa's rule had began to crumble. She had amassed too much influence and Camarilla elders started to worry about how much power the Prince of the capital of a global superpower could exert. They found an ally in Vitel, who betrayed Marissa to a coterie of archons and blamed her death on the Giovanni.