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The Prophecy

When the snows consume the earth and the sun gutters like a candle in the wind then, and only then there will be born a woman the last Daughter of Eve, and in her there will be decided the fate of all. And you will not know this woman, except by themark of the moon on her and she will face treachery, hatred, and pain but in her is the last hope.
  —  Excerpt from the Beckett's Jyhad Diary

In Noddist eschatology, the Last Daughter of Eve is a mortal woman, identified by a moon-shaped birthmark. She will be a critical figure in deciding the fate of all creatures during Gehenna. Various Gehenna cults spend a lot of time looking for girls who meet the Last Daughter's (admittedly vague) description.

“Mark of the moon” isn’t exactly clear cut. It might refer to a birthmark, or the phase of the moon during birth or Embrace. It could also mean she is a seer, a werewolf descendant, or a member of Clan Malkavian. This ambiguity hasn’t stopped scores of Kindred looking for the Last Daughter though.

Her title is taken to imply that before Gehenna, the human race will decline or begin to die off. Days of Fire interprets this as a precipitous drop in female fertility rates as the Time of Judgment approaches.

Several characters bearing this crescent-shaped birthmark have appeared in various sourcebooks leading up to Gehenna: