Ilse Decameron, a vampire of clan Tremere, is on a mission to procure a mortal mage. On her trail is Kurt Westphal, a member of the rival Ventrue clan who is trying to uncover the Tremere's newest threat. He and Ilse uncover a web of betrayal, demonic pacts and a scheme which, if it succeeds, will spell the end of the vampire clans and forever change the face of the World of Darkness.
The novel focuses on a ritual which would use a mortal descendant of Etrius to reverse the vampire curse among members of the Tremere. The novel's settings include Miami, Los Angeles, London, Vienna and Berlin featuring characters from the Vampire: The Masquerade sourcebook settings with characters introduced in the Vampire: The Eternal Struggle card game.