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Malefactor can refer to:
- The Defiler caste of the Infernal Exalted in Exalted
- The Lammasu house of the Fallen, also known as Defilers, in Demon: The Fallen
- The Defiler, also known as Defiler-of-All or the Defiler Wyrm, an aspect of the Triatic Wyrm in Werewolf: The Apocalypse