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Baron Samedi is the name of one of the main loa of Haitian Vodou. It can refer to:
- Baron Samedi, patron of Voodoo in the Classic World of Darkness
- Baron Samedi, progenitor of the Samedi bloodline in Vampire: The Masquerade
- Baron Samedi, a putative patron of Les Mystères in Hunter: The Vigil
- Baron Samedi, one of the Loa in Scion