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Anathema can refer to:
- The Anathema placed on the Red List and hunted by Alastors in Vampire: The Masquerade
- Anathema, weaknesses that Heroes can inflict on Beasts in Beast: The Primordial
- The Exalted declared Anathema by their Dragon-Blooded usurpers (the Solars and Lunars, and now also the Abyssals) in Exalted
- Anathema, the third-tier Poltergeist Horror in Orpheus