Vampire: The Masquerade
The Followers of Set maintain a temple in Alexandria, the Court of Miracles. The city was also the birthplace of the Cult of Typhon Trismegistus, and their abandoned temple (the Typhoneum) still houses ancient lore.
Werewolf: The Apocalypse
Mummy: The Resurrection
In 132 CE, Horus commanded the Shemsu-Heru to disperse through the world and fight Apophis each in their own way; Alexandria became the central port and hub of their activities. The Viziers kept their council here until the Sixth Great Maelstrom.